

The strip was frequently a Serial, discussing various topics such as "Love is Hell", a 1984 "13-chapter miniseries" pontificating on love and relationships. Then-publisher of the Reader Jane Levine said Groening arrived at editor-in-chief James Vowell's office one day, showing him his "silly cartoons with the rabbit with one ear." After Groening left, Vowell came out of his office saying, "This guy is gonna be famous someday." Popular in the underground, Life in Hell was picked up by the Los Angeles Reader (an alternative weekly newspaper where Groening also worked as a typesetter, editor, paste-up artist and music critic) in 1980, where it began appearing weekly.

The first strip, entitled "Forbidden Words", appeared in the September/October issue. Life in Hell debuted as a comic strip in the avant-garde Wet magazine in 1978, to which Groening made his first professional cartoon sale. He also sold it for two dollars a copy at the " punk" corner of the record store in which he worked, Licorice Pizza on Sunset Boulevard. Groening photocopied and distributed the comic book to friends. He described it as "every ex-campus protester's, every Boomer idealist's, conception of what adult existence in the '80s had turned out to be." And then I had a series of lousy jobs." In the comic book, Groening attacked what many young adults found repellent: school, work, and love. It was inspired by his move to the city that year in an interview with Playboy, Groening commented on his arrival: "I got on a Friday night in August it was about a hundred and two degrees my car broke down in the fast lane of the Hollywood Freeway while I was listening to a drunken deejay who was giving his last program on a local rock station and bitterly denouncing the station's management. Life in Hell started in 1977 as a self-published comic book Groening used to describe life in Los Angeles to his friends.
